Fluorescence is one of the most widely used diagnostic tools to detect a variety of diseases. It is also typically regarded as the most sensitive technique as well. To detect diseases at the earliest stages, one has to get treatment before the disease has had a chance to take hold. Detection and imaging becomes constrained by the background signal. On the nanoscale time, backgrounds are typically short-lived, thus using long-lived fluorescence probes as biomarkers combined with time-gated detection allows for a significant suppression of an unwanted background. Joe and his team have developed a simple, new approach with bursts of closely-spaced laser excitation pulses that allows for many-fold increase in the intensity of a long-lived probe over the background. This technology can be easily implemented for biomedical diagnostics/imaging to significantly enhance the signal of long-lived probes over the background by almost 2 orders of magnitude.
Joe Kimball is currently a Post Doctoral fellow in the Chemistry and Biochemistry Department at the University of Arizona where he is developing a system for non-linear ultrafast spectroscopy for use in semiconductor nanocrystals, NV centers, and photosynthesis research for efficient solar energy.
He finished his Ph.D in physics in December 2015 at Texas Christian University. He has been involved in a wide variety of physical, biological, technical and statistical projects, including molecular rotors for detection of viscosity of cancer cells, porphyrins for photodynamic therapy, and multipulse excitation technology for increasing signal to noise ratio in imaging, an idea he shares in his his TEDxTCU 2015 talk.
This talk was given at a TEDx event using the TED conference format but independently organized by a local community. Learn more at http://ted.com/tedx